Cerebrospinal fluid fatty acids in glucocerebrosidase-associated Parkinson's disease.
Identifieur interne : 000E54 ( Main/Exploration ); précédent : 000E53; suivant : 000E55Cerebrospinal fluid fatty acids in glucocerebrosidase-associated Parkinson's disease.
Auteurs : Stefan P. Schmid [Allemagne] ; Erwin D. Schleicher ; Alexander Cegan ; Christian Deuschle ; Stephanie Baur ; Ann-Kathrin Hauser ; Matthis Synofzik ; Karin Srulijes ; Kathrin Brockmann ; Daniela Berg ; Walter MaetzlerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- chemical , cerebrospinal fluid : Fatty Acids.
- chemical , genetics : Glucosylceramidase.
- cerebrospinal fluid : Parkinson Disease.
- genetics : Mutation, Parkinson Disease.
- Aged, Aged, 80 and over, Female, Heterozygote, Humans, Male, Middle Aged.
Abstract
Heterozygous mutations in the glucocerebrosidase gene lead to an increased risk for and to more severe alpha-synuclein-associated pathology in Parkinson's disease. As both glucocerebrosidase and alpha-synuclein interact with fatty acids, we hypothesized that cerebrospinal fluid fatty acid levels are altered in these Parkinson's disease patients.
DOI: 10.1002/mds.23984
PubMed: 22021190
Affiliations:
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Le document en format XML
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Schleicher</name></author><author><name sortKey="Cegan, Alexander" sort="Cegan, Alexander" uniqKey="Cegan A" first="Alexander" last="Cegan">Alexander Cegan</name></author><author><name sortKey="Deuschle, Christian" sort="Deuschle, Christian" uniqKey="Deuschle C" first="Christian" last="Deuschle">Christian Deuschle</name></author><author><name sortKey="Baur, Stephanie" sort="Baur, Stephanie" uniqKey="Baur S" first="Stephanie" last="Baur">Stephanie Baur</name></author><author><name sortKey="Hauser, Ann Kathrin" sort="Hauser, Ann Kathrin" uniqKey="Hauser A" first="Ann-Kathrin" last="Hauser">Ann-Kathrin Hauser</name></author><author><name sortKey="Synofzik, Matthis" sort="Synofzik, Matthis" uniqKey="Synofzik M" first="Matthis" last="Synofzik">Matthis Synofzik</name></author><author><name sortKey="Srulijes, Karin" sort="Srulijes, Karin" uniqKey="Srulijes K" first="Karin" last="Srulijes">Karin Srulijes</name></author><author><name sortKey="Brockmann, Kathrin" sort="Brockmann, Kathrin" uniqKey="Brockmann K" first="Kathrin" last="Brockmann">Kathrin Brockmann</name></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name></author><author><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Fatty Acids (cerebrospinal fluid)</term><term>Female</term><term>Glucosylceramidase (genetics)</term><term>Heterozygote</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mutation (genetics)</term><term>Parkinson Disease (cerebrospinal fluid)</term><term>Parkinson Disease (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Fatty Acids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glucosylceramidase</term></keywords><keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mutation</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Heterozygote</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Heterozygous mutations in the glucocerebrosidase gene lead to an increased risk for and to more severe alpha-synuclein-associated pathology in Parkinson's disease. As both glucocerebrosidase and alpha-synuclein interact with fatty acids, we hypothesized that cerebrospinal fluid fatty acid levels are altered in these Parkinson's disease patients.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Tübingen</li></region><settlement><li>Tübingen</li></settlement></list><tree><noCountry><name sortKey="Baur, Stephanie" sort="Baur, Stephanie" uniqKey="Baur S" first="Stephanie" last="Baur">Stephanie Baur</name><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><name sortKey="Brockmann, Kathrin" sort="Brockmann, Kathrin" uniqKey="Brockmann K" first="Kathrin" last="Brockmann">Kathrin Brockmann</name><name sortKey="Cegan, Alexander" sort="Cegan, Alexander" uniqKey="Cegan A" first="Alexander" last="Cegan">Alexander Cegan</name><name sortKey="Deuschle, Christian" sort="Deuschle, Christian" uniqKey="Deuschle C" first="Christian" last="Deuschle">Christian Deuschle</name><name sortKey="Hauser, Ann Kathrin" sort="Hauser, Ann Kathrin" uniqKey="Hauser A" first="Ann-Kathrin" last="Hauser">Ann-Kathrin Hauser</name><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name><name sortKey="Schleicher, Erwin D" sort="Schleicher, Erwin D" uniqKey="Schleicher E" first="Erwin D" last="Schleicher">Erwin D. Schleicher</name><name sortKey="Srulijes, Karin" sort="Srulijes, Karin" uniqKey="Srulijes K" first="Karin" last="Srulijes">Karin Srulijes</name><name sortKey="Synofzik, Matthis" sort="Synofzik, Matthis" uniqKey="Synofzik M" first="Matthis" last="Synofzik">Matthis Synofzik</name></noCountry><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Schmid, Stefan P" sort="Schmid, Stefan P" uniqKey="Schmid S" first="Stefan P" last="Schmid">Stefan P. Schmid</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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